Wang L, Kuroiwa Y, Kamitani T, Takahashi T, Suzuki Y, Hasegawa O
Department of Neurology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
J Neurol Neurosurg Psychiatry. 1999 Oct;67(4):497-503. doi: 10.1136/jnnp.67.4.497.
Visual event related potentials (ERPs) were studied during an oddball paradigm, to testify whether cognitive slowing in Parkinson's disease exists and to investigate whether cognitive information processing can be influenced by different interstimulus intervals (ISIs) of an oddball task in patients with Parkinson's disease and normal subjects.
ERPs and reaction time were measured in 38 non-demented patients with Parkinson's disease and 24 healthy elderly subjects. A visual oddball paradigm was employed to evoke ERPs, at three different interstimulus (ISI) intervals: ISI(S), 1600 ms; ISI(M), 3100 ms; and ISI(L), 5100 ms. The effect of ISIs on ERPs and reaction time was investigated.
Compared with the normal subjects, P300 latency at Cz and Pz was significantly delayed after rare target stimuli in patients with Parkinson's disease only at ISI(L). Reaction time was prolonged in patients at all the three ISIs, compared with the normal controls. There was also significantly delayed N200 and reduced P300 amplitude at Cz and/or Pz to rare non-target stimuli in patients at the three ISIs, compared with the normal controls. During rare target visual stimulation, P300 latency and reaction time in the patients with Parkinson's disease and reaction time in the normal subjects were gradually prolonged as the ISI increased.
Prolonged N200 latency to rare non-target stimuli might indicate that automatic cognitive processing was slowed in Parkinson's disease. Cognitive processing reflected by P300 latency to rare target stimuli was influenced by longer ISI in patients with Parkinson's disease.
在奇偶数范式期间研究视觉事件相关电位（ERP），以证实帕金森病中是否存在认知减慢，并调查帕金森病患者和正常受试者中，奇偶数任务的不同刺激间隔（ISI）是否会影响认知信息处理。
对38例非痴呆帕金森病患者和24例健康老年受试者测量ERP和反应时间。采用视觉奇偶数范式，以三种不同的刺激间隔（ISI）诱发ERP：ISI（S），1600毫秒；ISI（M），3100毫秒；以及ISI（L），5100毫秒。研究ISI对ERP和反应时间的影响。
与正常受试者相比，仅在ISI（L）时，帕金森病患者在罕见目标刺激后，Cz和Pz处的P300潜伏期显著延迟。与正常对照组相比，患者在所有三种ISI下的反应时间均延长。在三种ISI下，与正常对照组相比，患者对罕见非目标刺激在Cz和/或Pz处的N200也显著延迟，P300波幅降低。在罕见目标视觉刺激期间，帕金森病患者的P300潜伏期和反应时间以及正常受试者的反应时间随着ISI增加而逐渐延长。
对罕见非目标刺激的N200潜伏期延长可能表明帕金森病中自动认知处理减慢。帕金森病患者中，对罕见目标刺激的P300潜伏期所反映的认知处理受较长ISI的影响。
