Nunes F, Rodrigues R, Meirinho M
Department of Obstetrics and Gynecology, Hospital Garcia de Orta, 2800 Almada, Portugal.
Am J Obstet Gynecol. 1999 Sep;181(3):626-9. doi: 10.1016/s0002-9378(99)70503-x.
We sought to evaluate the efficacy and safety of intravaginal misoprostol and dinoprostone for labor induction.
One hundred eighty-nine women with singleton term pregnancies and unfavorable cervices were randomly assigned to receive intravaginal misoprostol or dinoprostone. The outcome variables were change in Bishop score, time from application to active phase of labor and delivery, fetal and maternal morbidity, and the incidence of cesarean deliveries.
The interval from application of the initial dose to the beginning of the active phase of labor was 9.8 +/- 5.8 and 14.2 +/- 10.2 hours (P <.01), and the interval from initial dose to delivery was 15.3 +/- 9.8 and 19.1 +/- 13.2 hours (P =.027) for the misoprostol and dinoprostone groups, respectively. There were no significant differences in Bishop score change, cesarean delivery rate, and the incidence of tachysystole, hypersystole, and hyperstimulation. No maternal and neonatal adverse effects were noted.
Intravaginal misoprostol is more effective than intravaginal dinoprostone for labor induction in low-risk patients at term with unfavorable cervices.
我们旨在评估阴道内使用米索前列醇和地诺前列酮引产的有效性和安全性。
189名单胎足月妊娠且宫颈条件不佳的女性被随机分配接受阴道内米索前列醇或地诺前列酮治疗。观察指标包括 Bishop 评分的变化、从用药到进入产程活跃期及分娩的时间、胎儿和母亲的发病率以及剖宫产率。
米索前列醇组和地诺前列酮组从初始剂量用药到产程活跃期开始的间隔时间分别为 9.8±5.8 小时和 14.2±10.2 小时（P<.01），从初始剂量用药到分娩的间隔时间分别为 15.3±9.8 小时和 19.1±13.2 小时（P =.027）。Bishop 评分变化、剖宫产率以及子宫收缩过速、子宫收缩过强和子宫过度刺激的发生率无显著差异。未观察到母婴不良反应。
对于足月宫颈条件不佳的低风险患者，阴道内使用米索前列醇引产比阴道内使用地诺前列酮更有效。
