Maĭorov V I, Moskvitin A A
Department of Higher Nervous Activity, Lomonosov State University, Moscow.
Zh Vyssh Nerv Deiat Im I P Pavlova. 1999 Mar-Apr;49(2):279-86.
Activity of neurons in the motor cortex was recorded in anesthetized cats with glass micropipettes filled with bicuculline solution (bicuculline methiodide, 10 mM in 1 M NaCl). Under these conditions, the minimal (near-threshold) electrical stimulation of the area 5 of the parietal cortex evoked the late neuronal discharges (in 30-200-ms poststimulus interval) in the motor cortex. Such discharges resembled the late NMDA-dependent discharges recorded in the motor cortex of awake cats in response to stimulation of the parietal cortex, which produced the preliminary elaborated conditioned forepaw placing. Under the same conditions, tetanic stimulation of the parietal cortex (100 Hz, 10-20s) led to the long-term potentiation of the late response, which manifested itself as response amplitude augmentation and latency shortening.
用充满荷包牡丹碱溶液（甲基荷包牡丹碱，在1M氯化钠中为10mM）的玻璃微电极在麻醉猫身上记录运动皮层神经元的活动。在这些条件下，对顶叶皮层5区进行最小（接近阈值）的电刺激会在运动皮层诱发晚期神经元放电（在刺激后30 - 200毫秒的间隔内）。这种放电类似于在清醒猫的运动皮层中记录到的晚期NMDA依赖放电，该放电是对顶叶皮层刺激的反应，这种刺激会产生预先精心准备的条件性前爪放置。在相同条件下，对顶叶皮层进行强直刺激（100Hz，10 - 20秒）会导致晚期反应的长期增强，表现为反应幅度增加和潜伏期缩短。
