Fylan F, Harding G F, Edson A S, Webb R M
Clinical Neurophysiology Department, Aston University, Birmingham, UK.
Epilepsia. 1999;40 Suppl 4:28-30. doi: 10.1111/j.1528-1157.1999.tb00903.x.
We aimed to elucidate the mechanisms underlying video-game epilepsy by comparing the flicker- and spatial-frequency ranges over which photic and pattern stimulation elicited photoparoxysmal responses in two different populations: (a) 25 patients with a history of seizures experienced while playing video games; and (b) 25 age- and medication-matched controls with a history of photosensitive epilepsy, but no history of video-game seizures.
Abnormality ranges were determined by measuring photoparoxysmal EEG abnormalities as a function of the flicker frequency of patterned and diffuse intermittent photic stimulation (IPS) and the spatial frequency of patterns on a raster display.
There was no significant difference between the groups in respect of the abnormality ranges elicited by patterned or diffuse IPS or by spatial patterns. When the groups were compared at one specific IPS frequency (-50 Hz), however, the flicker frequency of European television displays, the video-game patients were significantly more likely to be sensitive.
The results suggest that video-game seizures are a manifestation of photosensitive epilepsy. The increased sensitivity of video-game patients to IPS at 50 Hz indicates that display flicker may underlie video-game seizures. The similarity in photic- and pattern-stimulation ranges over which abnormalities are elicited in video-game patients and controls suggests that all patients with photosensitive epilepsy may be predisposed toward video-game-induced seizures. Photosensitivity screening should therefore include assessment by using both IPS at 50 Hz and patterns displayed on a television or monitor with a 50-Hz frame rate.
我们旨在通过比较在两个不同人群中光刺激和图形刺激引发光阵发性反应的闪烁频率范围和空间频率范围，来阐明视频游戏性癫痫的潜在机制：(a) 25名有玩视频游戏时发作史的患者；(b) 25名年龄和用药情况相匹配、有光敏性癫痫病史但无视频游戏发作史的对照者。
通过测量光阵发性脑电图异常来确定异常范围，该异常是图案化和弥漫性间歇性光刺激（IPS）的闪烁频率以及光栅显示器上图案的空间频率的函数。
在由图案化或弥漫性IPS或空间图案引发的异常范围方面，两组之间没有显著差异。然而，当在一个特定的IPS频率（-50Hz，欧洲电视显示器的闪烁频率）下比较两组时，视频游戏患者明显更易敏感。
结果表明视频游戏性癫痫发作是光敏性癫痫的一种表现。视频游戏患者对50Hz的IPS敏感性增加表明显示器闪烁可能是视频游戏性癫痫发作的基础。视频游戏患者和对照者在引发异常的光刺激和图形刺激范围方面的相似性表明，所有光敏性癫痫患者可能都易患视频游戏诱发的癫痫发作。因此，光敏性筛查应包括使用50Hz的IPS以及以50Hz帧率在电视或显示器上显示的图案进行评估。
