Abbasi F, Facchini F, Humphreys M H, Reaven G M
Department of Medicine, Stanford University School of Medicine, CA 94305, USA.
Atherosclerosis. 1999 Sep;146(1):175-8. doi: 10.1016/s0021-9150(99)00132-x.
This study was initiated to test the hypothesis that plasma homocysteine concentrations are increased in insulin resistant individuals. For this purpose, the relationship between insulin resistance, as assessed by the steady-state plasma glucose (SSPG) concentration during the insulin suppression test, and fasting plasma homocysteine concentration was defined in 55 healthy volunteers. The results indicated that homocysteine concentrations did not vary as a function of SSPG concentrations (r = 0.02, P = 0.88). Furthermore, mean (+/- S.E.M.) plasma homocysteine concentrations were similar (8.2+/-0.4 vs. 8.7+/-0.7 micromol/l) in individuals classified as being either insulin sensitive (SSPG <100 mg/dl) or insulin resistant (SSPG >180 mg/dl). On the other hand, SSPG concentration was significantly correlated with fasting plasma insulin (r = 0.58, P<0.001), triglycerides (r = 0.34, P<0.05), and HDL-cholesterol (r = -0.36, P = 0.04) concentrations. These data strongly suggest that the increased risk of atherosclerosis associated with increased plasma homocysteine concentrations is unrelated to insulin resistance and/or the metabolic abnormalities associated with it.
本研究旨在验证胰岛素抵抗个体血浆同型半胱氨酸浓度升高这一假说。为此，在55名健康志愿者中确定了胰岛素抵抗（通过胰岛素抑制试验期间的稳态血浆葡萄糖（SSPG）浓度评估）与空腹血浆同型半胱氨酸浓度之间的关系。结果表明，同型半胱氨酸浓度并不随SSPG浓度而变化（r = 0.02，P = 0.88）。此外，被分类为胰岛素敏感（SSPG <100 mg/dl）或胰岛素抵抗（SSPG >180 mg/dl）的个体，其平均（±标准误）血浆同型半胱氨酸浓度相似（8.2±0.4对8.7±0.7 μmol/l）。另一方面，SSPG浓度与空腹血浆胰岛素（r = 0.58，P<0.001）、甘油三酯（r = 0.34，P<0.05）和高密度脂蛋白胆固醇（r = -0.36，P = 0.04）浓度显著相关。这些数据强烈表明，与血浆同型半胱氨酸浓度升高相关的动脉粥样硬化风险增加与胰岛素抵抗和/或与之相关的代谢异常无关。
