Araki H, Kawasaki M, Matsuka N, Nakatsuma A, Watanabe K, Futagami K, Gomita Y
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
Acta Med Okayama. 1999 Aug;53(4):185-8. doi: 10.18926/AMO/31615.
The effects of exposure to cigarette smoke on the pharmacokinetics and pharmacodynamics of zonisamide, an antiepileptic drug, were investigated in rats. Absorption of oral zonisamide was significantly inhibited by exposure to cigarette smoke. The Cmax, T1/2 and the area under the plasma concentration-time curve 0-24 values in the cigarette smoke exposure group were significantly lower than those in the control group. Although tonic extension (TE) induced by maximal electroshock was completely blocked by the administration of zonisamide in the control group, 50% of rats showed TE in the cigarette smoke exposure group. Exposure to cigarette smoke influences both the pharmacokinetics and antiepileptic effects of zonisamide. The effects of smoking on epileptic patients using zonisamide warrants further attention.
在大鼠中研究了接触香烟烟雾对一种抗癫痫药物唑尼沙胺的药代动力学和药效学的影响。接触香烟烟雾显著抑制了口服唑尼沙胺的吸收。香烟烟雾暴露组的Cmax、T1/2以及血浆浓度-时间曲线下0至24小时的面积值均显著低于对照组。虽然在对照组中，给予唑尼沙胺可完全阻断最大电休克诱导的强直伸展（TE），但在香烟烟雾暴露组中，50%的大鼠出现了TE。接触香烟烟雾会影响唑尼沙胺的药代动力学和抗癫痫作用。吸烟对使用唑尼沙胺的癫痫患者的影响值得进一步关注。
