Van Steirteghem A, Liebaers I, Camus M
Centre de médecine de la reproduction, Hôpital universitaire, Bruxelles, Belgique.
Rev Prat. 1999 Jun 15;49(12):1309-13.
Several etiological factors in male infertility have been identified and it is now clear that a proportion of these factors have a genetic basis. This implies that using assisted reproductive technology procedures and especially intracytoplasmic sperm injection these genetic factors may be transmitted to the children. The following genetic factors involved in severe male infertility will be discussed: the presence of numerical and structural chromosomal anomalies, the occurrence of microdeletions on the long arm of the Y chromosome and the relation between cystic fibrosis and congenital bilateral absence of the vas deferens.
