Zenker F, Barajas J J
Clínica Barajas, Santa Cruz de Tenerife, Canary Islands, Spain.
Int J Psychophysiol. 1999 Aug;33(2):99-111. doi: 10.1016/s0167-8760(99)00033-1.
The P300 (P3) event-related brain potential (ERP) was elicited with auditory stimuli in order to compare three different tasks and to assess the effect of ageing from childhood to adolescence. Seventy-two subjects, ranging in age from 6 to 14 divided into three age groups, were selected for this study. In the active task, the subject was required to discriminate between standard and target tones (oddball); in the passive task condition, the subject did not respond to either the standard or target stimulus; in the single task, a target but not a standard tone stimulus was presented and the subject was required to react to the target tone. Our results show that the passive sequence and the single-tone paradigm yielded similar P300 waveform to those obtained from the active task. Separate age/ERP component latency and amplitude linear regression were computed. A significant negative correlation between age and P3 latency was found. The event-related potential P3 wave shows consistent and significant age-related changes in human cerebral function, regardless of the methodology used. These findings suggest that the passive and single-tone paradigms can be a useful way to elicit the P3 ERP component.
为了比较三种不同任务并评估从童年到青少年时期衰老的影响，采用听觉刺激诱发P300（P3）事件相关脑电位（ERP）。本研究选取了72名年龄在6至14岁之间的受试者，并将其分为三个年龄组。在主动任务中，受试者需要区分标准音和目标音（oddball范式）；在被动任务条件下，受试者对标准刺激或目标刺激均不做出反应；在单一任务中，只呈现目标音而非标准音刺激，受试者需要对目标音做出反应。我们的结果表明，被动序列和单音范式产生的P300波形与主动任务获得的波形相似。计算了单独的年龄/ERP成分潜伏期和振幅线性回归。发现年龄与P3潜伏期之间存在显著的负相关。无论使用何种方法，事件相关电位P3波在人类脑功能中均显示出与年龄相关的一致且显著的变化。这些发现表明，被动和单音范式可能是诱发P3 ERP成分的一种有用方法。
