Andersen U B, Dige-Petersen H, Ibsen H, Skøtt P, Bruun N E, Vestergaard H, Christiansen C
Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, Denmark.
J Hypertens. 1999 Sep;17(9):1273-80. doi: 10.1097/00004872-199917090-00006.
To study insulin resistance in subjects with strong genetic predisposition to essential hypertension, compared with non-disposed subjects.
Thirty normotensive subjects aged 18-35 years whose parents both had essential hypertension, and 30 age- and sex matched subjects whose parents were both normotensive, were studied. Subjects or parents with diabetes and morbid obesity were excluded.
The study comprised (1) a frequent sampling oral glucose tolerance test; (2) an isoglycemic hyperinsulinemic clamp study; (3) an analysis of body composition by dual-energy X-ray absorptiometry; (4) an exercise test with gas exchange analysis; and (5) investigation of composition of usual diet by diet registration for 5 days.
The 24-h diastolic blood pressure was higher in subjects predisposed to hypertension compared with the controls: 78.1 versus 74.0 mmHg (confidence interval for the difference between the means; -0.5; -7.9), but the insulin sensitivity index was similar: 312 versus 362 I(2) min(-1) pmol(-1) kg(-1) (28; -129). The two groups were similar in terms of body composition, exercise capacity and composition of usual diet. Resting and 24-h diastolic blood pressures were correlated to abdominal fat mass but not to insulin sensitivity.
Subjects with a strong genetic predisposition to essential hypertension had increased diastolic blood pressure compared with subjects with normotensive parents, but they were not insulin resistant. This may be due to the subjects being highly selected as to confounding factors. The increased blood pressure in the hypertension prone subjects could not be attributed to differences in body composition, exercise capacity or dietary habits.
与无原发性高血压遗传易感性的受试者相比，研究有原发性高血压强遗传易感性受试者的胰岛素抵抗情况。
研究了30名年龄在18 - 35岁的血压正常受试者，其父母均患有原发性高血压，以及30名年龄和性别匹配、父母血压均正常的受试者。排除患有糖尿病和病态肥胖的受试者或其父母。
该研究包括：（1）频繁采样口服葡萄糖耐量试验；（2）等血糖高胰岛素钳夹研究；（3）通过双能X线吸收法分析身体成分；（4）进行气体交换分析的运动试验；（5）通过5天饮食记录调查日常饮食组成。
与对照组相比，有高血压遗传易感性的受试者24小时舒张压更高：分别为78.1 mmHg和74.0 mmHg（均值差异的置信区间为 - 0.5至 - 7.9），但胰岛素敏感性指数相似：分别为312和362 I(2) min(-1) pmol(-1) kg(-1)（28至 - 129）。两组在身体成分、运动能力和日常饮食组成方面相似。静息和24小时舒张压与腹部脂肪量相关，但与胰岛素敏感性无关。
与父母血压正常的受试者相比，有原发性高血压强遗传易感性的受试者舒张压升高，但他们不存在胰岛素抵抗。这可能是由于在混杂因素方面对受试者进行了高度筛选。高血压易感受试者血压升高不能归因于身体成分、运动能力或饮食习惯的差异。
