Powaser M M, Brown M C, Chezem J, Woodburne C R, Rogenes P, Hanson B
Heart Lung. 1976 Sep-Oct;5(5):734-41.
The efficacy of hourly endotracheal tube cuff deflations in minimizing tracheal damage has not been clearly established. Two investigations which specifically address this question arrive at differing conclusions. These investigations fail to report important variables which may have explained the difference in their results. The present study examined the effects of hourly cuff deflations in minimizing tracheal damage in mechanically ventilated, anesthetized dogs over a 72 hour test period. Variables which may influence tracheal damage were measured and reported. Three groups of dogs received either continuous cuff inflation, hourly 5 minute cuff deflations, or a continuous air leak. The air leak group had significanlty less damage than the continuous inflation group (P less than 0.05) and the hourly deflation group (P less than 0.01). There was no significant difference between the continuous inflation group and the 5 minute hourly deflation group.
每小时进行气管导管套囊放气以将气管损伤降至最低的效果尚未明确确定。两项专门针对这个问题的研究得出了不同的结论。这些研究未能报告可能解释其结果差异的重要变量。本研究在72小时的测试期内，研究了每小时进行套囊放气对机械通气麻醉犬气管损伤最小化的影响。测量并报告了可能影响气管损伤的变量。三组犬分别接受持续套囊充气、每小时5分钟套囊放气或持续漏气。漏气组的损伤明显少于持续充气组（P<0.05）和每小时放气组（P<0.01）。持续充气组和每小时5分钟放气组之间没有显著差异。
