Herszényi L
II sz. Belgyógyászati Klinika, Semmelweis Orvostudományi Egyetem, Budapest.
Orv Hetil. 1999 Aug 8;140(32):1771-7.
Gastric cancer is a rather common solid tumour world-wide. Although it has been made advances in the diagnosis and treatment, its prognosis has not improved significantly in recent years. Now, greater attention has been gained into the biological behaviour of gastric tumour cells, how they become malignant and what mechanisms are involved during the process of invasions and metastasis. This process involves the tumour-associated protease cascade, changes in genetics and loss or mutation of adhesion molecules. Such biological tumour characteristic features may provide new prognostic factors in gastric cancer and also potential target for future therapeutic concepts. This is an update of prognostic factors in gastric cancer, pointing out new functional biological features, some of which have been investigated by our group over the past few years.
胃癌是一种在全球范围内相当常见的实体瘤。尽管在诊断和治疗方面已经取得了进展，但近年来其预后并未显著改善。现在，人们越来越关注胃肿瘤细胞的生物学行为，它们如何变得恶性以及在侵袭和转移过程中涉及哪些机制。这个过程涉及肿瘤相关蛋白酶级联反应、遗传学变化以及黏附分子的缺失或突变。这些生物学肿瘤特征可能为胃癌提供新的预后因素，也是未来治疗理念的潜在靶点。这是一篇关于胃癌预后因素的综述，指出了新的功能性生物学特征，其中一些特征在过去几年里已由我们团队进行了研究。
