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Synthesis and biological acitivity of annulated pyrazoles as selective COX-2 inhibitors. I.

作者信息

Kim H H, Park J G, Moon T C, Chang H W, Jahng Y

机构信息

College of Pharmacy, Yeungnam University Kyongsan, Korea.

出版信息

Arch Pharm Res. 1999 Aug;22(4):372-9. doi: 10.1007/BF02979060.

DOI:10.1007/BF02979060
PMID:10489876
Abstract

A series of disubstituted 4,5-polymethylenepyrazoles were synthesized and evaluated their inhibitory activities against COX-2. Some compounds showed strong (0.3 nM) inhibitory activity on COX-2 and were found somewhat selective (up to 16) on COX-2 over COX-1.

摘要

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