Harshfield G A, Treiber F A
Georgia Prevention Institute, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia 30912-4534, USA.
Blood Press Monit. 1999 Jun-Aug;4(3-4):107-10.
Many pathologic conditions are characterized by a blunted nocturnal decline in blood pressure.
To review the evidence that African Americans display a similar pattern and examine factors associated with the pattern.
We reviewed published racial comparisons of patterns of ambulatory blood pressure in adults and youths.
Authors of 15 studies reported finding blunted nocturnal declines in African Americans and authors of two studies did not. Authors of studies of Africans in Africa and of blacks from other countries reported normal nocturnal declines. Both intake of sodium and indexes of body size have been related to nocturnal blood pressure in African-American youths. This pattern is related to greater than normal target-organ changes.
; We conclude that the race of a patient should be considered when evaluating a 24h pattern of blood pressure in an adolescent; and the blunted nocturnal decline displayed by many African-American adolescents is the result of a gene-environment interaction and therefore is susceptible to modification through changes in diet, level of activity, and other environmental factors.
许多病理状况的特征是夜间血压下降不明显。
回顾非裔美国人呈现类似模式的证据，并研究与该模式相关的因素。
我们回顾了已发表的关于成年人和青少年动态血压模式的种族比较研究。
15项研究的作者报告称发现非裔美国人夜间血压下降不明显，两项研究的作者则未发现此现象。非洲的非洲人以及其他国家黑人的研究作者报告夜间血压下降正常。钠摄入量和体型指标均与非裔美国青少年的夜间血压有关。这种模式与比正常情况更严重的靶器官变化有关。
我们得出结论，在评估青少年24小时血压模式时应考虑患者的种族；许多非裔美国青少年夜间血压下降不明显是基因与环境相互作用的结果，因此可通过饮食、活动水平和其他环境因素的改变而得到改善。
