灵长类视网膜中蓝黄视锥神经节细胞的感受野微观结构

Receptive-field microstructure of blue-yellow ganglion cells in primate retina.

作者信息

Chichilnisky E J, Baylor D A

机构信息

Department of Neurobiology, Stanford University, School of Medicine, Stanford, California 94305, USA.

出版信息

Nat Neurosci. 1999 Oct;2(10):889-93. doi: 10.1038/13189.

DOI:10.1038/13189

PMID:10491609

Abstract

We examined the functional microcircuitry of cone inputs to blue-ON/yellow-OFF (BY) ganglion cells in the macaque retina using multielectrode recording. BY cells were identified by their ON responses to blue light and OFF responses to red or green light. Cone-isolating stimulation indicated that ON responses originated in short (S) wavelength-sensitive cones, whereas OFF responses originated in both long (L) and middle (M) wavelength-sensitive cones. Stimulation with fine spatial patterns revealed locations of individual S cones in BY cell receptive fields. Neighboring BY cells received common but unequal inputs from one or more S cones. Inputs from individual S cones differed in strength, indicating different synaptic weights, and summed approximately linearly to control BY cell firing.

摘要

我们使用多电极记录技术研究了猕猴视网膜中蓝光开启/黄光关闭（BY）神经节细胞的视锥细胞输入功能微电路。通过对蓝光的开启反应和对红光或绿光的关闭反应来识别BY细胞。视锥细胞分离刺激表明，开启反应起源于短（S）波长敏感视锥细胞，而关闭反应起源于长（L）和中（M）波长敏感视锥细胞。精细空间模式刺激揭示了BY细胞感受野中单个S视锥细胞的位置。相邻的BY细胞从一个或多个S视锥细胞接收共同但不相等的输入。来自单个S视锥细胞的输入强度不同，表明突触权重不同，并大致线性相加以控制BY细胞的放电。