Piatkowska-Jakubas B, Hawrylecka D, Wójcik M, Skotnicki A B
Kliniki Hematologii Collegium Medicum, Uniwersytetu Jagiellońskiego.
Przegl Lek. 1999;56 Suppl 1:108-14.
Infectious complications remain one of the most serious diagnostic and therapeutic problems in modern hematology and are the major cause of morbidity and mortality following stem cell transplantation. Myeloablative therapy supported by haemopoietic stem cell transplantation remains standard policy in the treatment of certain haematological malignancies and solid tumors. Proper preventive strategies for patients in deep immunosuppression including prompt diagnosis and treatment of infections correlate with favourable prognosis and survival. Prophylaxis and therapy of bacterial, fungal and viral infections in neutropenic patients following myeloablative chemotherapy have been submitted in this article. Our guidelines are based on European Group for Bone and Marrow Transplantation recommendations and some European transplantological centres protocols. These standards were adapted to Polish conditions and now are used at Bone Marrow Transplantation Ward at Haematology Department at the Jagiellonian University.
感染性并发症仍然是现代血液学中最严重的诊断和治疗问题之一，并且是干细胞移植后发病和死亡的主要原因。造血干细胞移植支持下的清髓性疗法仍是治疗某些血液系统恶性肿瘤和实体瘤的标准方案。针对深度免疫抑制患者的适当预防策略，包括及时诊断和治疗感染，与良好的预后和生存率相关。本文介绍了清髓性化疗后中性粒细胞减少患者细菌、真菌和病毒感染的预防和治疗。我们的指南基于欧洲骨髓移植组的建议以及一些欧洲移植中心的方案。这些标准已根据波兰的情况进行了调整，目前在雅盖隆大学血液学系骨髓移植病房使用。
