Knowles S R
Sunnybrook & Women's College Health Sciences Centre, Toronto, Canada.
Can J Clin Pharmacol. 1999 Autumn;6(3):137-48.
When choosing an anticonvulsant drug, factors such as efficacy, pharmacokinetics, cost, teratogenic effects and potential adverse effects of the drug, and age and sex of the patient must be considered. Adverse effects are observed in up to one-third of patients on anticonvulsant therapy and are divided into two groups - common dose-related toxicity and idiosyncratic toxicity. Both types of adverse events associated with anticonvulsants are discussed according to the organ system affected. Postmarketing surveillance of the newer anticonvulsants is vital to monitor potentially rare idiosyncratic reactions or chronic toxicities.
选择抗惊厥药物时，必须考虑药物的疗效、药代动力学、成本、致畸作用和潜在不良反应，以及患者的年龄和性别等因素。高达三分之一接受抗惊厥治疗的患者会出现不良反应，这些不良反应分为两组——常见的剂量相关毒性和特异质性毒性。根据受影响的器官系统讨论与抗惊厥药物相关的这两种不良事件。对新型抗惊厥药物进行上市后监测对于监测潜在的罕见特异质性反应或慢性毒性至关重要。
