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新斯科舍省老年人口中苯二氮䓬类药物使用流行率的人口趋势:值得担忧吗?

Population trends in the prevalence of benzodiazepine use in the older population of Nova Scotia: A cause for concern?

作者信息

Rojas-Fernandez C H, Carver D, Tonks R

机构信息

Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo 79106-1712, USA.

出版信息

Can J Clin Pharmacol. 1999 Autumn;6(3):149-56.

Abstract

Because benzodiazepines can cause significant morbidity and data of their use in elderly people in Canada are scarce, the patterns of benzodiazepine use by Nova Scotia's seniors were studied with the use of administrative, population-based data. The prevalence of benzodiazepine use in the fiscal years 1993/94 to 1995/96 was explored, the types of benzodiazepines used and the extent of use for periods exceeding 30 days were examined, and an attempt was made to examine the average daily doses used. Benzodiazepine use decreased from 28.74% in 1993/94 to 24.69% in 1995/96 (P<0.001). Long elimination half-life benzodiazepines accounted for 23% of benzodiazepines in 1995/96. The proportion of benzodiazepines filled for periods exceeding 30 days increased from 65% in 1993/94 to 68% in 1995/96 (P<0.001). Variability in the estimated daily doses of the benzodiazepines was such that comparison with recommended dose maxima could not be made with confidence, even though the averages of these estimated daily doses appeared to exceed recommended maxima, except for users of alprazolam, lorazepam, oxazepam or bromazepam. Although benzodiazepine use decreased, the observed patterns of use may place seniors at unnecessary risk for adverse health outcomes and increased health resource utilization.

摘要

由于苯二氮䓬类药物可导致严重发病情况,且加拿大老年人使用此类药物的数据匮乏,因此利用基于人群的行政数据对新斯科舍省老年人使用苯二氮䓬类药物的模式进行了研究。探讨了1993/94财政年度至1995/96财政年度苯二氮䓬类药物的使用 prevalence,检查了所使用的苯二氮䓬类药物类型以及超过30天的使用 extent,并尝试检查平均每日剂量。苯二氮䓬类药物的使用从1993/94年的28.74%降至1995/96年的24.69%(P<0.001)。长效消除半衰期的苯二氮䓬类药物在1995/96年占苯二氮䓬类药物的23%。超过30天的苯二氮䓬类药物处方比例从1993/94年的65%增至1995/96年的68%(P<0.001)。苯二氮䓬类药物估计每日剂量的变异性很大,以至于即使这些估计每日剂量的平均值似乎超过了推荐最大值,但除阿普唑仑、劳拉西泮、奥沙西泮或溴西泮使用者外,无法自信地与推荐剂量最大值进行比较。尽管苯二氮䓬类药物的使用有所减少,但观察到的使用模式可能会使老年人面临不必要的不良健康后果风险和增加卫生资源利用。

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