Andreishcheva E N, Zviagil'skaia R A
Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russia.
Prikl Biokhim Mikrobiol. 1999 May-Jun;35(3):243-56.
Mechanisms underlying adaptation of various yeasts to salt stress were summarized. Stress response involves modulation of enzymatic activities and changes in gene expression. Elevated salinity of the environment can be regarded as a two-factor stress process that includes an osmotic component leading to loss of cellular turgor and a toxic component inhibiting a set of functions due to an increase in the intracellular concentration of Na+. Adaptation of yeast cells to these stress conditions obligatorily involves the accumulation of osmotically active compounds (mainly glycerol) to counterbalance an increased external osmotic pressure and the modification of plasma membrane transport systems to extrude Na+ from the cell.
总结了各种酵母适应盐胁迫的潜在机制。应激反应涉及酶活性的调节和基因表达的变化。环境盐度升高可被视为一个双因素应激过程，包括导致细胞膨压丧失的渗透成分和由于细胞内Na+浓度增加而抑制一系列功能的毒性成分。酵母细胞适应这些应激条件必然涉及渗透活性化合物（主要是甘油）的积累，以平衡增加的外部渗透压，以及质膜转运系统的修饰，以将Na+从细胞中排出。
