Paleologos N A, Macdonald D R, Vick N A, Cairncross J G
Division of Neurology, Evanston Hospital, IL 60201, USA.
Neurology. 1999 Sep 22;53(5):1141-3. doi: 10.1212/wnl.53.5.1141.
The authors reviewed the results of neoadjuvant (preradiation) procarbazine, CCNU, and vincristine chemotherapy for anaplastic oligodendrogliomas because, increasingly, chemotherapy is prescribed before radiation for oligodendroglial neoplasms. The data indicate that 70% of patients respond to neoadjuvant chemotherapy, whereas 30% require early radiation because they either have chemoresistant tumors or experience unacceptable chemotoxicity.
作者回顾了对间变性少突胶质细胞瘤进行新辅助（放疗前）甲基苄肼、洛莫司汀和长春新碱化疗的结果，因为越来越多的少突胶质细胞瘤在放疗前就开始进行化疗。数据表明，70%的患者对新辅助化疗有反应，而30%的患者由于肿瘤具有化疗耐药性或出现不可接受的化学毒性而需要早期放疗。
