Espey M G, Ellis R J, Heaton R K, Basile A S
Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Neurology. 1999 Sep 22;53(5):1144-5. doi: 10.1212/wnl.53.5.1144.
Chronic hyperactivation of excitatory amino acid pathways in the CNS of patients infected with HIV-1 may contribute to the pathogenesis of HIV-1-associated dementia complex. However, no correlation between the concentration of glutamate in CSF (mean 3.3 micromol/L) and either HIV-1 infection or HIV-1-associated dementia complex was observed. The results clarify several important issues regarding analysis of glutamate in the CSF and the role of excitotoxins in HIV-1-associated dementia complex.
人类免疫缺陷病毒1型（HIV-1）感染患者中枢神经系统中兴奋性氨基酸途径的慢性过度激活可能导致HIV-1相关痴呆综合征的发病机制。然而，未观察到脑脊液中谷氨酸浓度（平均3.3微摩尔/升）与HIV-1感染或HIV-1相关痴呆综合征之间存在相关性。这些结果阐明了脑脊液中谷氨酸分析以及兴奋性毒素在HIV-1相关痴呆综合征中的作用的几个重要问题。
