Cagnacci A, Modena M G, Malmusi S, Muia N, Volpe A
Institute of Obstetric and Gynecology, University of Modena, Italy.
Am J Cardiol. 1999 Aug 1;84(3):367-70, A9-10. doi: 10.1016/s0002-9149(99)00300-8.
In 15 postmenopausal women with no cardiovascular risk factors, hormone replacement with transdermal estradiol (50 microg/day for 2 months) did not enhance flow-mediated endothelium-dependent vasodilation, reduce endothelium-independent vasodilation, and did not modify the pulsatility index and blood flow of the brachial artery. The present data do not support a positive effect of replacement with transdermal estradiol on vessel vasodilation in healthy, postmenopausal women.
在15名无心血管危险因素的绝经后女性中，经皮雌二醇激素替代治疗（50微克/天，持续2个月）并未增强血流介导的内皮依赖性血管舒张、降低非内皮依赖性血管舒张，也未改变肱动脉的搏动指数和血流。目前的数据不支持经皮雌二醇替代治疗对健康绝经后女性血管舒张有积极作用。
