Jensen-Urstad K, Johansson J, Jensen-Urstad M
Karolinska Institute, Department of Clinical Physiology, Södersjukhuset, Stockholm, Sweden.
J Intern Med. 1997 Jun;241(6):507-13. doi: 10.1111/j.1365-2796.1997.tb00009.x.
To investigate whether, in a healthy, randomly selected population of 35-year-old men and women, there is a relation between vascular function and conventional risk factors for cardiovascular disease such as gender, smoking, elevated blood-lipids, high blood pressure and heredity for cardiovascular disease, and to blood glucose.
Basal brachial artery diameter was measured. Endothelial function was measured as flow mediated dilation (FMD) in response to reactive hyperaemia. The nonendothelial dependent dilation was measured after sublingual nitro-glycerine (NTG).
A research centre of general medicine and a university hospital.
One hundred men and 100 women all 35 years old, were invited by letter. Sixty-six of the 92 men (72%) living in the community and 74 of the 88 women (84%) participated.
Gender had the largest influence on FMD and NTG induced arterial dilation, probably reflecting the larger vessel diameters in the men as FMD and NTG induced dilation is inversely related to basal vessel size (r = -0.55, P < 0.001 and r = -0.40, P < 0.001). In women basal vessel diameter was positively correlated to blood glucose (r = 0.35, P = 0.009) and BMI (r = 0.34, P = 0.012) and negatively correlated to HDL cholesterol (r = -0.43, P = 0.001). FMD and NTG induced arterial dilation correlated with a combined risk factor score (r = -0.32, P = 0.019 and r = -0.31, P = 0.024). The men with the highest risk factor scores had larger vessel size and higher blood flow at rest compared to men without risk factors (4.8 +/- 0.6 mm, 240 +/- 84 mL min-1 and 4.0 +/- 0.8 mm, 139 +/- 72 mL min-1, respectively, P = 0.014 and P = 0.016). FMD or NTG induced dilation did not correlate to any of the risk factors in men.
There are correlations between vascular reactivity and risk factors for IHD in women and correlations between vessel diameter and risk factors for IHD in both men and women already in a healthy population 35-year-old subjects. Further studies are needed to determine if the vessel diameter in itself, in a healthy population, is a sign of attenuated endothelial function.
在随机选取的35岁健康男性和女性人群中，研究血管功能与心血管疾病的传统危险因素（如性别、吸烟、血脂升高、高血压、心血管疾病遗传因素）以及血糖之间是否存在关联。
测量肱动脉基础直径。通过反应性充血时的血流介导的血管舒张（FMD）来测量内皮功能。在舌下含服硝酸甘油（NTG）后测量非内皮依赖性血管舒张。
一家普通医学研究中心和一家大学医院。
通过信函邀请了100名35岁的男性和100名35岁的女性。社区中92名男性中的66名（72%）以及88名女性中的74名（84%）参与了研究。
性别对FMD和NTG诱导的动脉舒张影响最大，这可能反映出男性的血管直径较大，因为FMD和NTG诱导的舒张与基础血管大小呈负相关（r = -0.55，P < 0.001和r = -0.40，P < 0.001）。在女性中，基础血管直径与血糖呈正相关（r = 0.35，P = 0.009）和BMI呈正相关（r = 0.34，P = 0.012），与高密度脂蛋白胆固醇呈负相关（r = -0.43，P = 0.001）。FMD和NTG诱导的动脉舒张与综合危险因素评分相关（r = -0.32，P = 0.019和r = -0.31，P = 0.024）。与无危险因素的男性相比，危险因素评分最高的男性基础血管尺寸更大，静息时血流量更高（分别为4.8±0.6 mm，240±84 mL·min-1和4.0±0.8 mm，139±72 mL·min-1，P = 0.014和P = 0.016）。FMD或NTG诱导的舒张与男性的任何危险因素均无相关性。
在35岁的健康人群中，女性的血管反应性与缺血性心脏病危险因素之间存在相关性，男性和女性的血管直径与缺血性心脏病危险因素之间均存在相关性。需要进一步研究以确定在健康人群中血管直径本身是否是内皮功能减弱的一个标志。
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