Duquette-Petersen L, Francis M E, Dohnalek L, Skinner R, Dudas P
Georgetown University Medical Center, Washington, DC, USA.
Oncol Nurs Forum. 1999 Sep;26(8):1319-24.
PURPOSE/OBJECTIVES: To determine the efficacy of cover gowns and shoe covers in the prevention of infection in patients undergoing autologous bone marrow transplantation (BMT).
Randomized two-group controlled clinical trial.
Adult BMT unit of a university teaching hospital in the Southeastern United States.
40 women and men receiving an autologous BMT for hematologic and solid tumor malignancies. Patients were assigned randomly to control or experimental groups. Thirty-one patients completed the study. Inclusion criteria required that patients be at least 18 years of age and not have received a previous autologous BMT.
Data were collected from the patients' medical records. Characteristics of the distributions for the main research variables were compared between the control group (caregivers who wore cover gowns and shoe covers) and experimental group (caregivers who wore no covers).
Time to first antibiotic treatment and length of antibiotic therapy.
Cover gowns and shoe covers worn by caregivers provided no benefit for this group of 31 patients. The differences in time to first antibiotic and length of antibiotic treatment were not statistically significant between the two groups.
The mean and median number of hours to first antibiotic treatment for adult autologous BMT recipients in the control group exceeded the corresponding time for those in the experimental group by only one hour and four hours, respectively. The potential benefits and risks of cover gown and shoe cover usage by caregivers of autologous BMT recipients should be reexamined in larger randomized trials.
The elimination of cover gowns and shoe covers in caring for patients undergoing autologous BMT will save nursing time and hospital resources as well as eliminate one isolation barrier experienced by patients.
目的/目标：确定隔离衣和鞋套在预防接受自体骨髓移植（BMT）患者感染方面的效果。
随机两组对照临床试验。
美国东南部一所大学教学医院的成人BMT科室。
40名因血液系统和实体肿瘤恶性疾病接受自体BMT的男女患者。患者被随机分配至对照组或试验组。31名患者完成了研究。纳入标准要求患者年龄至少18岁且之前未接受过自体BMT。
从患者病历中收集数据。比较对照组（穿着隔离衣和鞋套的护理人员）和试验组（未穿隔离衣和鞋套的护理人员）主要研究变量的分布特征。
首次抗生素治疗时间和抗生素治疗时长。
护理人员穿着隔离衣和鞋套对这31名患者并无益处。两组在首次使用抗生素时间和抗生素治疗时长方面的差异无统计学意义。
对照组中成年自体BMT受者首次接受抗生素治疗的平均小时数和中位数小时数仅分别比试验组受者超出1小时和4小时。应在更大规模的随机试验中重新审视自体BMT受者护理人员使用隔离衣和鞋套的潜在益处和风险。
在护理接受自体BMT的患者时不使用隔离衣和鞋套将节省护理时间和医院资源，同时消除患者所经历的一个隔离屏障。
