Teramoto S, Suzuki M, Matsui H, Ishii T, Matsuse T, Ouchi Y
Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan.
J Asthma. 1999 Sep;36(6):487-92. doi: 10.3109/02770909909054554.
We evaluated variations in spirometric indices (i.e., forced vital capacity [FVC], peak expiratory flow [PEF], and forced expiratory volume in 1 sec [FEV1]) and static respiratory muscle pressures (i.e., maximum static inspiratory pressure [PImax] and maximum static expiratory pressure [PEmax]) within a span of 12 hr in 60 healthy elderly subjects, 60 young subjects, and 30 Chronic Obstructive Pulmonary disease (COPD) patients. There were no differences among data of FVC, PEF, FEV1, PImax, and PEmax on three separate occasions within a day in the elderly or the young. The mean coefficient of variation (CV) values of PEF and PImax on three occasions were 3.0 +/- 0.3% and 4.2 +/- 0.4% in the elderly, and 2.4 +/- 0.2% and 3.7 +/- 0.3% in the young, respectively. No subjects had more than 9% CV on each measurement in the study, suggesting that there is nosignificant daytime variation in measurement of expiratory flow and respiratory pressures in young and elderly people. However, FVC, PEF FEV1, and PImax values in the morning were smaller than those measured at the other two occasions in COPD patients. The results indicate that COPD affects diurnal variation in pulmonary function, but age alone has little impact on diurnal variation.
我们评估了60名健康老年人、60名年轻人和30名慢性阻塞性肺疾病（COPD）患者在12小时内肺量计指标（即用力肺活量[FVC]、呼气峰值流速[PEF]和1秒用力呼气量[FEV1]）以及静态呼吸肌压力（即最大静态吸气压力[PImax]和最大静态呼气压力[PEmax]）的变化情况。老年人或年轻人在一天内三个不同时间点的FVC、PEF、FEV1、PImax和PEmax数据之间没有差异。老年人三次测量时PEF和PImax的平均变异系数（CV）值分别为3.0±0.3%和4.2±0.4%，年轻人分别为2.4±0.2%和3.7±0.3%。在该研究中，没有受试者每次测量的CV超过9%，这表明年轻人和老年人的呼气流量和呼吸压力测量在白天没有显著变化。然而，COPD患者早晨的FVC、PEF、FEV1和PImax值低于其他两个时间点测量的值。结果表明，COPD会影响肺功能的昼夜变化，但仅年龄对昼夜变化影响不大。
