Shu X O, Stewart P, Wen W Q, Han D, Potter J D, Buckley J D, Heineman E, Robison L L
Department of Pediatrics, University of Minnesota, Minneapolis 55454, USA.
Cancer Epidemiol Biomarkers Prev. 1999 Sep;8(9):783-91.
Parental exposure to hydrocarbons at work has been suggested to increase the risk of childhood leukemia. Evidence, however, is not entirely consistent. Very few studies have evaluated the potential parental occupational hazards by exposure time windows. The Children's Cancer Group recently completed a large-scale case-control study involving 1842 acute lymphocytic leukemia (ALL) cases and 1986 matched controls. The study examined the association of self-reported occupational exposure to various hydrocarbons among parents with risk of childhood ALL by exposure time window, immunophenotype of ALL, and age at diagnosis. We found that maternal exposure to solvents [odds ratio (OR), 1.8; 95% confidence interval (CI), 1.3-2.5] and paints or thinners (OR, 1.6; 95% CI, 1.2-2.2) during the preconception period (OR, 1.6; 95% CI, 1.1-2.3) and during pregnancy (OR, 1.7; 95% CI, 1.2-2.3) and to plastic materials during the postnatal period (OR, 2.2; 95% CI, 1.0-4.7) were related to an increased risk of childhood ALL. A positive association between ALL and paternal exposure to plastic materials during the preconception period was also found (OR, 1.4; 95% CI, 1.0-1.9). The ALL risk associated with parental exposures to hydrocarbons did not vary greatly with immunophenotype of ALL. These results suggest that the effect of parental occupational exposure to hydrocarbons on offspring may depend on the type of hydrocarbon and the timing of the exposure.
有研究表明，父母在工作中接触碳氢化合物会增加儿童患白血病的风险。然而，证据并不完全一致。很少有研究按接触时间窗评估潜在的父母职业危害。儿童癌症研究组最近完成了一项大规模病例对照研究，涉及1842例急性淋巴细胞白血病（ALL）病例和1986例匹配对照。该研究按接触时间窗、ALL的免疫表型和诊断年龄，研究了父母自我报告的各种碳氢化合物职业接触与儿童ALL风险之间的关联。我们发现，母亲在孕前（比值比[OR]，1.8；95%置信区间[CI]，1.3 - 2.5）、孕期（OR，1.6；95% CI，1.2 - 2.2）接触溶剂（OR，1.6；95% CI，1.1 - 2.3）和油漆或稀释剂，以及产后接触塑料材料（OR，2.2；95% CI，1.0 - 4.7）与儿童ALL风险增加有关。还发现ALL与父亲孕前接触塑料材料之间存在正相关（OR，1.4；95% CI，1.0 - 1.9）。与父母接触碳氢化合物相关的ALL风险在ALL的免疫表型方面变化不大。这些结果表明，父母职业接触碳氢化合物对后代的影响可能取决于碳氢化合物的类型和接触时间。
