recD sbcB sbcD突变体在通过RecBC对紫外线损伤进行重组修复方面存在缺陷。
recD sbcB sbcD mutants are deficient in recombinational repair of UV lesions by RecBC.
作者信息
Seigneur M, Ehrlich S D, Michel B
机构信息
Génétique Microbienne, Institut National de la Recherche Agronomique, 78352 Jouy en Josas Cedex, France.
出版信息
J Bacteriol. 1999 Oct;181(19):6220-1. doi: 10.1128/JB.181.19.6220-6221.1999.
Abstract
In recD sbcB sbcD mutants, repair of UV-irradiated DNA is strongly RecF dependent, indicating that RecBC is inactive. This finding suggests that exonuclease V, exonuclease I (SbcB), and the SbcCD nuclease play a redundant role in vivo, which is essential for the recombination activity of the RecBC complex during UV repair.
摘要
在recD sbcB sbcD突变体中，紫外线照射后DNA的修复强烈依赖于RecF，这表明RecBC无活性。这一发现表明，核酸外切酶V、核酸外切酶I（SbcB）和SbcCD核酸酶在体内发挥冗余作用，这对于RecBC复合物在紫外线修复过程中的重组活性至关重要。
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