通过配体交换毛细管电泳法对手性拟交感神经药进行手性分离。
Chiral separation of sympathomimetics by ligand exchange capillary electrophoresis.
作者信息
Schmid M G, Laffranchini M, Dreveny D, Gübitz G
机构信息
Institute of Pharmaceutical Chemistry, Karl-Franzens University, Graz, Austria.
出版信息
Electrophoresis. 1999 Sep;20(12):2458-61. doi: 10.1002/(SICI)1522-2683(19990801)20:12<2458::AID-ELPS2458>3.0.CO;2-8.
A rapid and simple approach to the chiral separation of sympathomimetic drugs with amino alcohol structure by ligand exchange capillary electrophoresis is described. An N-(2-hydroxyoctyl)-L-4-hydroxyproline/copper(II) complex is used as chiral selector. Thirteen sympathomimetics were resolved, nine with baseline resolution. The influence of pH and composition of the electrolyte on resolution was investigated. The optimal pH for complexation of these amino alcohols was found to be 12.
描述了一种通过配体交换毛细管电泳对手性分离具有氨基醇结构的拟交感神经药物的快速简便方法。使用N-(2-羟基辛基)-L-4-羟基脯氨酸/铜(II)络合物作为手性选择剂。分离出了13种拟交感神经药物，其中9种达到基线分离。研究了pH值和电解质组成对分离度的影响。发现这些氨基醇络合的最佳pH值为12。
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