Filliat P, Baubichon D, Burckhart M F, Pernot-Marino I, Foquin A, Masqueliez C, Perrichon C, Carpentier P, Lallement G
Unité de Neuropharmacologie, Centre de Recherches du Service de Santé des Armées Emile Parde, La Tronche, France. 100437,
Neurotoxicology. 1999 Aug;20(4):535-49.
The effects of soman, a potent irreversible inhibitor of acetylcholinesterase, on central neuropathology in rats were studied in relation with subsequent spatial memory impairments. In a first step, it was found that, without treatment, neuropathology and learning impairment were observed only in rats which experienced convulsions. Then, treatment consisting of atropine sulfate, and/or TCP and/or NBQX was administered to intoxicated animals at infraanticonvulsant doses to obtain a graded subsequent neuropathology and to appreciate an eventual relation between neuropathology and spatial memory impairment. Thus, a correlation between neuropathology in the hippocampal CA1 region and spatial learning performance was found, the degradation of performance of rat being directly related to the amplitude of their neural damage. A threshold was emphasized : below a certain degree of neural loss, no memory impairment was found. Only treatment with tritherapy (atropine + TCP + NBQX) was able to improve the different parameters of spatial learning, despite no effect on the convulsions of the animals.
研究了强效不可逆乙酰胆碱酯酶抑制剂梭曼对大鼠中枢神经病理学的影响及其与随后空间记忆障碍的关系。第一步发现，未经治疗时，仅在经历惊厥的大鼠中观察到神经病理学和学习障碍。然后，以低于抗惊厥剂量向中毒动物施用由硫酸阿托品和/或TCP和/或NBQX组成的治疗，以获得分级的后续神经病理学，并评估神经病理学与空间记忆障碍之间的最终关系。因此，发现海马CA1区的神经病理学与空间学习性能之间存在相关性，大鼠性能的下降与神经损伤的程度直接相关。强调了一个阈值：低于一定程度的神经损失，未发现记忆障碍。尽管对动物惊厥没有影响，但仅三联疗法（阿托品+TCP+NBQX）治疗能够改善空间学习的不同参数。
