Sepúlveda J, Astorga J G, Contreras E
Department of Pharmacology, Faculty of Biological Sciences, University of Concepción, Chile.
Eur J Pharmacol. 1999 Aug 20;379(1):59-62. doi: 10.1016/s0014-2999(99)00503-8.
The effects of the antiglutamatergic agent, riluzole, were examined on the antinociceptive action of morphine, on the induction of physical dependence, and on the expression of the abstinence syndrome to the opiate in mice. Morphine was administered as a single dose (200 mg/kg) of a slow-release preparation. Acute and chronic administration of riluzole decreased the analgesic response to morphine, the intensity of abstinence behavior (administered 30 min before a dose of naloxone), and the development of physical dependence (repeatedly administered during the period of chronic morphine treatment).
研究了抗谷氨酸能药物利鲁唑对小鼠吗啡的抗伤害感受作用、身体依赖性诱导以及对阿片类药物戒断综合征表达的影响。吗啡以单剂量（200 mg/kg）缓释制剂给药。利鲁唑的急性和慢性给药降低了对吗啡的镇痛反应、戒断行为的强度（在纳洛酮给药前30分钟给药）以及身体依赖性的发展（在慢性吗啡治疗期间重复给药）。
