Seeger U, Klose U, Lutz O, Grodd W
Sektion Exp. MR des ZNS, Abteilung für Neuroradiologie and Physikalisches Institut, Universität Tubingen, Germany.
Magn Reson Imaging. 1999 Oct;17(8):1219-26. doi: 10.1016/s0730-725x(99)00060-0.
Short echo time 1H NMR spectra of the human brain reveal signals from various metabolites. In addition, resonances from macromolecules are present that may provide further useful information in several brain diseases. The detection of all these signals is possible if excellent volume selection is obtained; even small lipid contamination from surrounding fat tissue leads to strong spectral contamination. It affects the macromolecule resonances in the 0.5 to 2.0 ppm region and some adjacent metabolite signals and jeopardizes their quantitative analysis. This paper demonstrates how spatial contamination from insufficiently dephased signals can be recognized, analysed, and removed in localized STEAM spectroscopy of the brain.
