Amagasaki K, Yamazaki H, Koizumi H, Hashizume K, Sasaguchi N
Department of Neurosurgery, Yamanashi Prefectural Central Hospital, Kofu, Yamanashi, Japan.
Childs Nerv Syst. 1999 Sep;15(9):482-5. doi: 10.1007/s003810050444.
A 25-year-old woman presented with recurrent medulloblastoma. She had been diagnosed with cerebellar medulloblastoma and treated for it at the age of 5 years. The new tumor was partially resected and chemotherapy was begun. However, a disseminated tumor of the spine was discovered and, despite radiotherapy, the patient became comatose and died. Histological examination of the tumor specimen showed characteristics similar to those of the first tumor. Late recurrence of medulloblastoma is rare, and a latency period of 19 years is the longest reported. This case violates Collins' rule and exceeds other proposed periods of risk. Extension of the period of follow-up in patients with medulloblastoma is advocated.
一名25岁女性患有复发性髓母细胞瘤。她在5岁时被诊断出患有小脑髓母细胞瘤并接受了治疗。新肿瘤部分切除后开始化疗。然而，发现了脊柱播散性肿瘤，尽管进行了放疗，患者仍昏迷并死亡。肿瘤标本的组织学检查显示其特征与第一个肿瘤相似。髓母细胞瘤的晚期复发很少见，报道的最长潜伏期为19年。该病例违反了柯林斯法则，超过了其他提出的风险期。提倡延长髓母细胞瘤患者的随访期。
