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异质人群中的肾移植:蒙特菲奥里医疗中心三十年经验

Renal transplantation in a heterogeneous population: the thirty-year Montefiore Medical Center experience.

作者信息

Greenstein S M, Kim D, Principe A, Ong E, Chin W, Glicklich D, Schechner R, Tellis V

机构信息

Montefiore Medical Center-Albert Einstein College of Medicine, Bronx, New York, USA.

出版信息

Clin Transpl. 1998:187-93.

Abstract

Based on more than 30 years of renal transplantation experience at Montefiore Medical Center we conclude: 1. Improved patient and graft survival can be achieved in the cadaveric transplant recipient despite increasing co-morbidities. 2. Patients at the extremes of age (< 10 or > 60) can undergo renal transplantation safely, with patient and graft survival rates approaching those of the general recipient population. 3. Results of transplantation in African-Americans are as good as non African-Americans at 3 years. Beyond that point the graft survival curves diverge. Well matched (0-1 HLA mismatches) kidneys in the African-American patient do as well if not better than other ethnic groups. However, African-Americans do not receive as many well matched kidneys as others.

摘要

基于蒙特菲奥里医疗中心30多年的肾移植经验,我们得出以下结论:1. 尽管合并症增多,但尸体肾移植受者的患者及移植物存活率仍可提高。2. 年龄极端的患者(<10岁或>60岁)可安全地接受肾移植,其患者及移植物存活率接近一般受者人群。3. 非裔美国人肾移植3年的结果与非非裔美国人一样好。超过这一阶段,移植物存活曲线出现分化。非裔美国患者中HLA错配为0-1个的匹配良好的肾脏,即便不比其他种族群体更好,至少也一样好。然而,非裔美国人获得的匹配良好的肾脏数量不如其他种族。

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