Ogawa D, Uemura N, Sasaki N, Mukai T, Yamaguchi S, Okamoto S, Yamamoto S, Mashiba H, Taniyama K
Department of Gastroenterology, Kure Kyosai Hospital, Japan.
J Med. 1998;29(5-6):381-93.
We report a case of complete and spontaneous regression of malignant lymphoma of the stomach. A submucosal tumor with central ulceration was detected on the greater curvature of the stomach in a 63-year-old woman. The tumor was diagnosed histopathologically as a diffuse large B-cell lymphoma (REAL classification). The tumor disappeared 18 days later without chemotherapy. Examination at that stage showed Helicobacter pylori (H. pylori), which was later treated with antibiotics. There was no evidence of recurrence of the malignant lymphoma at the last follow-up conducted at the time of preparation of this report, 13 months after the initial diagnosis. Spontaneous regression of an intermediate and high-grade non-Hodgkin's lymphoma is uncommon. We discuss the possible role of H. pylori in the regression of gastric malignant lymphomas.
我们报告一例胃恶性淋巴瘤完全自发消退的病例。一名63岁女性的胃大弯处发现一个伴有中央溃疡的黏膜下肿瘤。该肿瘤经组织病理学诊断为弥漫性大B细胞淋巴瘤（REAL分类）。18天后，未经化疗，肿瘤消失。当时的检查发现幽门螺杆菌（H. pylori），随后用抗生素进行了治疗。在本报告撰写时，即初次诊断13个月后的最后一次随访中，没有恶性淋巴瘤复发的证据。中高级别非霍奇金淋巴瘤的自发消退并不常见。我们讨论了幽门螺杆菌在胃恶性淋巴瘤消退中可能发挥的作用。
