Misselwitz B, Platzek J, Radüchel B, Oellinger J J, Weinmann H J
Research Laboratories of Schering AG, Diagnostic Imaging Division, Contrast Media Research, Berlin, Germany.
MAGMA. 1999 Aug;8(3):190-5. doi: 10.1007/BF02594598.
Differential diagnosis of malignant and beign lymph nodes is still a problem in lymphographic imaging modalities. Plain magnetic resonance imaging (MRI) and computed tomography (CT) are inadequate for detecting metastases in normal-sized lymph nodes and for differentiating enlarged nodes. Therefore it is important to have a contrast agent that accumulates in healthy lymphatic tissue but does not accumulate in metastatic deposits.
The lymphographic contrast agent Gadofluorine 8 (Schering AG, Berlin, Germany) is a lipophilic but water-soluble gadolinium complex. Lymphographic effects were investigated in guinea pigs, dogs, and tumor-bearing rabbits after interstitial (subcutaneous or intracutaneous) injection. MR imaging was performed using T1-weighted gradient-echo sequences until 120 min after administration.
After interstitial injection Gadofluorine 8 accumulates in regional lymph nodes, resulting in a pronounced increase in signal intensity in the lymph nodes. Differentiation between normal and metastatic lymph nodes was achieved.
Gadofluorine 8 is an innovative contrast agent that can distinguish between normal and tumorous lymph nodes in interstitial MR lymphography.
在淋巴造影成像方式中，恶性和良性淋巴结的鉴别诊断仍是一个问题。普通磁共振成像（MRI）和计算机断层扫描（CT）在检测正常大小淋巴结中的转移灶以及区分肿大淋巴结方面存在不足。因此，拥有一种能在健康淋巴组织中积聚但不在转移灶中积聚的造影剂很重要。
淋巴造影剂钆双胺（德国柏林先灵公司）是一种亲脂性但水溶性的钆络合物。在豚鼠、狗和荷瘤兔经间质（皮下或皮内）注射后研究其淋巴造影效果。使用T1加权梯度回波序列进行磁共振成像，直至给药后120分钟。
经间质注射后，钆双胺积聚在局部淋巴结中，导致淋巴结信号强度显著增加。实现了正常淋巴结与转移淋巴结的区分。
钆双胺是一种创新的造影剂，可在间质磁共振淋巴造影中区分正常和肿瘤性淋巴结。
