Choi Seung Hong, Han Moon Hee, Moon Woo Kyung, Son Kyu Ri, Won Jae-Kyung, Kim Ji-Hoon, Kwon Bae Ju, Na Dong Gyu, Weinmann Haans-Joachim, Chang Kee-Hyun
Department of Radiology and Institute of Radiation Medicine, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea.
Radiology. 2006 Dec;241(3):753-62. doi: 10.1148/radiol.2413051979. Epub 2006 Oct 10.
To prospectively compare the accuracy of gadofluorine M with that of monocrystalline iron oxide nanoparticle (MION)-47 for the depiction of cervical lymph node metastases at magnetic resonance (MR) imaging in a rabbit model of head and neck cancer by using histologic analysis as the reference standard.
Experiments were approved by the animal care committee. VX2 carcinomas were implanted in both ears of 11 rabbits 4 weeks before MR imaging. T2-weighted, T2*-weighted, and T1-weighted MR images were acquired, and sequential T1-weighted MR imaging was performed immediately and 30 minutes after administration of gadofluorine M (0.05 mmol gadolinium per kilogram body weight). T2-weighted and T2*-weighted MR imaging were performed 24 hours after administration of MION-47 (2.6 mg iron per kilogram body weight). Gadofluorine M- and MION-47-enhanced MR imaging were performed separately and independently by two radiologists who had no knowledge of histopathologic results, and the presence of metastases in lymph nodes was evaluated. A receiver operating characteristic analysis was conducted to compare the diagnostic value of gadofluorine M- and MION-47-enhanced MR imaging.
Metastases were confirmed in 20 of 77 lymph nodes at histopathologic analysis. The area under the curve was significantly greater for gadofluorine M-enhanced MR imaging (0.997 and 0.981 for readers 1 and 2, respectively) than for MION-47-enhanced MR imaging (0.889 and 0.846 for readers 1 and 2, respectively). For gadofluorine M-enhanced MR imaging, sensitivity was 100% for both readers and specificity was 89.5% for reader 1 and 87.7% for reader 2. For MION-47-enhanced MR imaging, sensitivity was 80.0% for both readers and specificity was 75.4% for reader 1 and 71.9% for reader 2.
Gadofluorine M-enhanced MR imaging has higher accuracy for depicting lymph node metastases than does MION-47-enhanced MR imaging.
通过使用组织学分析作为参考标准，前瞻性比较钆弗塞胺M与单晶氧化铁纳米颗粒（MION）-47在头颈部癌兔模型磁共振（MR）成像中对颈部淋巴结转移灶的显示准确性。
实验经动物护理委员会批准。在MR成像前4周，将VX2癌植入11只兔子的双耳。采集T2加权、T2加权和T1加权MR图像，并在静脉注射钆弗塞胺M（每千克体重0.05 mmol钆）后立即及30分钟后进行连续T1加权MR成像。在静脉注射MION-47（每千克体重2.6 mg铁）24小时后进行T2加权和T2加权MR成像。钆弗塞胺M和MION-47增强的MR成像由两名对组织病理学结果不知情的放射科医生分别独立进行，评估淋巴结转移灶的存在情况。进行受试者操作特征分析以比较钆弗塞胺M和MION-47增强MR成像的诊断价值。
组织病理学分析证实77个淋巴结中有20个存在转移。钆弗塞胺M增强MR成像的曲线下面积（读者1和读者2分别为0.997和0.981）显著大于MION-47增强MR成像（读者1和读者2分别为0.889和0.846）。对于钆弗塞胺M增强MR成像，两位读者的敏感性均为100%，读者1的特异性为89.5%，读者2的特异性为87.7%。对于MION-47增强MR成像，两位读者的敏感性均为80.0%，读者1的特异性为75.4%，读者2的特异性为71.9%。
钆弗塞胺M增强MR成像在显示淋巴结转移灶方面比MION-47增强MR成像具有更高的准确性。
