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Adequacy of high-dose cefepime regimen in febrile neutropenic patients with hematological malignancies.大剂量头孢吡肟方案在血液系统恶性肿瘤发热性中性粒细胞减少患者中的疗效
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Clinical pharmacodynamics of antipseudomonal cephalosporins in patients with ventilator-associated pneumonia.抗假单胞菌头孢菌素类药物在呼吸机相关性肺炎患者中的临床药效学
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本文引用的文献

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Continuous infusion ceftazidime in intensive care: a randomized controlled trial.重症监护中持续输注头孢他啶：一项随机对照试验。
J Antimicrob Chemother. 1999 Feb;43(2):309-11. doi: 10.1093/jac/43.2.309.
2
The pharmacodynamics of beta-lactams.β-内酰胺类药物的药效学
Clin Infect Dis. 1998 Jul;27(1):10-22. doi: 10.1086/514622.
3
Intermittent bolus dosing of ceftazidime in critically ill patients.危重症患者中头孢他啶的间歇性推注给药
J Antimicrob Chemother. 1997 Aug;40(2):269-73. doi: 10.1093/jac/40.2.269.
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High-performance liquid chromatographic assay for cefepime in serum.
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Subtleties of antibiotic dosages--do doses and intervals make a difference in the critically ill?抗生素剂量的细微差别——剂量和给药间隔对重症患者有影响吗？
S Afr J Surg. 1996 Nov;34(4):160-2.
6
Efficacy of cefepime in the treatment of infections due to multiply resistant Enterobacter species.头孢吡肟治疗多重耐药肠杆菌属所致感染的疗效。
Clin Infect Dis. 1996 Sep;23(3):454-61. doi: 10.1093/clinids/23.3.454.
7
Continuous infusion versus intermittent administration of ceftazidime in critically ill patients with suspected gram-negative infections.头孢他啶持续输注与间歇给药用于疑似革兰阴性菌感染的重症患者的比较。
Antimicrob Agents Chemother. 1996 Mar;40(3):691-5. doi: 10.1128/AAC.40.3.691.
8
Changes in vancomycin pharmacokinetics in critically ill infants.危重症婴儿万古霉素药代动力学的变化
Anaesth Intensive Care. 1995 Dec;23(6):678-82. doi: 10.1177/0310057X9502300603.
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Plasma protein binding and pharmacological response.血浆蛋白结合与药理反应。
Clin Pharmacokinet. 1993 Jun;24(6):435-40. doi: 10.2165/00003088-199324060-00001.
10
In-vitro activity of cefepime against bacterial pathogens from hospitalized patients.头孢吡肟对住院患者细菌病原体的体外活性。
J Antimicrob Chemother. 1993 Jul;32(1):164-6. doi: 10.1093/jac/32.1.164.

重症脓毒症患者血浆头孢吡肟水平较低：药代动力学模型表明，调整给药方案可提高谷浓度。

Low plasma cefepime levels in critically ill septic patients: pharmacokinetic modeling indicates improved troughs with revised dosing.

作者信息

Lipman J, Wallis S C, Rickard C

机构信息

Division of Anaesthesiology and Intensive Care, University of Queensland, Queensland, Australia.

出版信息

Antimicrob Agents Chemother. 1999 Oct;43(10):2559-61. doi: 10.1128/AAC.43.10.2559.

DOI:10.1128/AAC.43.10.2559
PMID:10508045
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC89521/
Abstract

The pharmacokinetics of a 2-g bolus of cefepime were measured in critically ill patients with normal renal function. Variable and low trough plasma drug concentrations were found, and 8 of 10 patients had levels below the MIC at which 50% of the isolates are inhibited for Pseudomonas aeruginosa. Computer simulations predicted that continuous infusion and shorter dosing intervals would increase trough levels.

摘要

对肾功能正常的重症患者测定了2克头孢吡肟大剂量注射后的药代动力学。发现血浆药物谷浓度变化不定且较低，10名患者中有8名患者的谷浓度低于铜绿假单胞菌50%分离株被抑制的最低抑菌浓度（MIC）。计算机模拟预测持续输注和缩短给药间隔会提高谷浓度。