Bernardi P
Department of Biomedical Sciences, University of Padova, and Consiglio Nazionale delle Ricerche Center for the Study of Biomembranes, Padova, Italy.
Physiol Rev. 1999 Oct;79(4):1127-55. doi: 10.1152/physrev.1999.79.4.1127.
This review provides a selective history of how studies of mitochondrial cation transport (K+, Na+, Ca2+) developed in relation to the major themes of research in bioenergetics. It then covers in some detail specific transport pathways for these cations, and it introduces and discusses open problems about their nature and physiological function, particularly in relation to volume regulation and Ca2+ homeostasis. The review should provide the basic elements needed to understand both earlier mitochondrial literature and current problems associated with mitochondrial transport of cations and hopefully will foster new interest in the molecular definition of mitochondrial cation channels and exchangers as well as their roles in cell physiology.
本综述选择性地回顾了线粒体阳离子转运（K⁺、Na⁺、Ca²⁺）研究如何与生物能量学的主要研究主题相关联而发展。接着详细涵盖了这些阳离子的特定转运途径，并介绍和讨论了有关其性质和生理功能的未解决问题，特别是与体积调节和Ca²⁺稳态相关的问题。本综述应提供理解早期线粒体文献以及当前与线粒体阳离子转运相关问题所需的基本要素，并有望激发人们对线粒体阳离子通道和交换体的分子定义及其在细胞生理学中的作用产生新的兴趣。
