一种小分子胍盐受体：精氨酸塞子。
A Small-Molecule Guanidinium Receptor: The Arginine Cork.
作者信息
Bell TW, Khasanov AB, Drew MG, Filikov A, James TL
机构信息
Department of Chemistry, University of Nevada, Reno, NV 89557-0020 (USA).
出版信息
Angew Chem Int Ed Engl. 1999 Sep;38(17):2543-2547. doi: 10.1002/(sici)1521-3773(19990903)38:17<2543::aid-anie2543>3.0.co;2-9.
A highly preorganized, artificial receptor for guanidinium cations binds arginine with high affinity in polar solvents, even in water! The X-ray crystal structure of its bis(N-ethylguanidinium) complex shows the formation of hydrogen bonds between the receptor and the guest (see picture). This observation explains the strength of the complex formed with the dipeptide diarginine (K(d)=50 µM in H(2)O).
一种高度预组织的胍盐阳离子人工受体在极性溶剂中，甚至在水中都能以高亲和力结合精氨酸！其二（N-乙基胍盐）配合物的X射线晶体结构表明受体与客体之间形成了氢键（见图）。这一观察结果解释了与二肽双精氨酸形成的配合物的强度（在H₂O中K(d)=50 µM）。
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