Federico M
Laboratory of Virology Istituto Superiore di Sanità Viale Regina Elena 299 00161, Rome, Italy.
Curr Opin Biotechnol. 1999 Oct;10(5):448-53. doi: 10.1016/s0958-1669(99)00008-7.
Lentivirus vectors are already used as effective gene delivery tools in cells from liver, retina, skeletal muscle and the central nervous system. In the past year, new and exciting data from gene transfer experiments in human hematopoietic progenitor cells have been obtained. Furthermore, new generations of HIV-1 based lentivirus vectors as well as new potentially less pathogenic HIV-2 based vectors have been described; however, old and new obstacles remain to be cleared.
慢病毒载体已被用作向肝脏、视网膜、骨骼肌和中枢神经系统的细胞中有效递送基因的工具。在过去的一年里，已获得了有关人类造血祖细胞基因转移实验的新的、令人兴奋的数据。此外，已描述了新一代基于HIV-1的慢病毒载体以及新的潜在致病性较低的基于HIV-2的载体；然而，新旧障碍仍有待清除。
