Tsukita S, Furuse M, Itoh M
Department of Cell Biology Faculty of Medicine Kyoto University Yoshida-Konoe, Sakyo-ku, Kyoto, 606, Japan.
Curr Opin Cell Biol. 1999 Oct;11(5):628-33. doi: 10.1016/s0955-0674(99)00016-2.
Tight junctions (TJs) have been suggested to act both as barriers and fences, but lack of information on the constituents of TJ strands has hampered the direct assessment of these functions. Over the past year, our understanding of the molecular architecture of TJ strands has increased markedly and we are ready to experimentally examine how TJs are involved in their dual functions.
紧密连接（TJs）被认为兼具屏障和围栏的作用，但由于缺乏关于紧密连接链成分的信息，阻碍了对这些功能的直接评估。在过去的一年里，我们对紧密连接链分子结构的理解有了显著提高，并且我们准备通过实验来研究紧密连接如何参与其双重功能。
