Dasen J S, Rosenfeld M G
Howard Hughes Medical Institute Cellular and Molecular Medicine University of California San Diego, Department and School of Medicine La Jolla, California, 92093-0648, USA.
Curr Opin Genet Dev. 1999 Oct;9(5):566-74. doi: 10.1016/s0959-437x(99)00015-5.
The development of the hormone-secreting cell types in the pituitary gland provides an excellent model system in which to explore the complex transcriptional mechanisms underlying the specification and maintenance of differentiated cell types in mammalian organogenesis. Pituitary development is orchestrated through the combinatorial actions of a repertoire of signaling-gradient-induced transcription factors which, on the basis of their distinct and overlapping expression patterns, and functional interactions, ultimately has led to the generation of functionally distinct cell phenotypes from a common ectodermal primordium.
垂体中分泌激素的细胞类型的发育提供了一个出色的模型系统，用于探索哺乳动物器官发生中分化细胞类型的特化和维持所涉及的复杂转录机制。垂体发育是由一系列信号梯度诱导的转录因子的组合作用精心编排的，这些转录因子基于其独特且重叠的表达模式以及功能相互作用，最终导致从共同的外胚层原基产生功能不同的细胞表型。
