Takalo R, Korhonen I, Majahalme S, Tuomisto M, Turjanmaa V
Department of Clinical Physiology, Uppsala University Hospital, Sweden.
Am J Hypertens. 1999 Sep;12(9 Pt 1):874-81. doi: 10.1016/s0895-7061(99)00069-2.
Electrocardiogram and intraarterial blood pressure (BP) were recorded in 35 normotensive (NT), 29 borderline hypertensive (BHT), and 30 mildly hypertensive (HT) men (aged 35 to 45 years) by the Oxford method over a 24-h period. Consecutive data segments of 5 min were extracted from the recordings for frequency domain analysis. Heart rate (HR) and BP variability was calculated for oscillations between 0.05 and 0.12 Hz, usually referred to as Mayer waves. Power and median frequency of the oscillations were determined. Some 10% of the segments were excluded from the analysis because of artifacts and transients. The results were averaged for 5-h periods in the evening, at night, and during the day. In the BHT subjects, the median frequency of the Mayer waves was shifted to lower frequencies as compared with the NT subjects. This was seen at night and during the day. The phenomenon presumably reflects an increased latency in the sympathetic vasomotor control of the baroreceptor reflex. No between-group differences were found in the normalized spectral power values. Five years later, 24 NT, 22 BHT, and 19 HT subjects were reassessed using casual BP and noninvasive ambulatory 24-h monitoring. In the initial phase, the median frequencies for the 5-h periods showed no evident linear relationship with the corresponding BP levels. However, the median frequencies showed high inverse correlations with the follow-up ambulatory BP levels. In the evening and during the day, the median frequency showed a significant inverse correlation also with the increment in BP. No clear relationship was found between power estimates and BP levels or future increments in BP. In conclusion, the frequency shift of Mayer waves to lower frequencies is associated with an increased risk of developing established hypertension.
采用牛津方法，在24小时内记录了35名血压正常（NT）、29名临界高血压（BHT）和30名轻度高血压（HT）男性（年龄35至45岁）的心电图和动脉内血压（BP）。从记录中提取连续5分钟的数据段进行频域分析。计算心率（HR）和血压变异性，用于分析0.05至0.12Hz之间的振荡，通常称为迈耶波。确定振荡的功率和中位数频率。由于伪迹和瞬变，约10%的数据段被排除在分析之外。结果在晚上、夜间和白天的5小时时间段内进行平均。与NT受试者相比，BHT受试者的迈耶波中位数频率向较低频率偏移。这种情况在夜间和白天都能看到。该现象可能反映了压力感受器反射的交感血管运动控制中潜伏期增加。在归一化频谱功率值方面未发现组间差异。五年后，使用偶测血压和无创动态24小时监测对24名NT、22名BHT和19名HT受试者进行了重新评估。在初始阶段，5小时时间段的中位数频率与相应的血压水平没有明显的线性关系。然而，中位数频率与随访的动态血压水平呈高度负相关。在晚上和白天，中位数频率也与血压增量呈显著负相关。在功率估计值与血压水平或未来血压增量之间未发现明确关系。总之，迈耶波向较低频率的频率偏移与发展为确诊高血压的风险增加有关。
