Matsuda H, Shimoda H, Uemura T, Yoshikawa M
Kyoto Pharmaceutical University, Japan.
Bioorg Med Chem Lett. 1999 Sep 20;9(18):2647-52. doi: 10.1016/s0960-894x(99)00442-4.
The methanolic extract from the leaves of Laurus nobilis (bay leaf, laurel) potently inhibited the elevation of blood ethanol level in ethanol-loaded rat. Through bioassay-guided separation, costunolide, dehydrocostus lactone, and santamarine were isolated as the active constituents and the alpha-methylene-gamma-butyrolactone structure was found to be essential for the preventive effect on ethanol absorption. In addition, the retardation of gastric emptying seemed to be partially involved in the preventive effects.
月桂叶的甲醇提取物能有效抑制乙醇负荷大鼠血液乙醇水平的升高。通过生物测定导向分离，分离出木香烯内酯、脱氢木香内酯和异土木香碱作为活性成分，发现α-亚甲基-γ-丁内酯结构对预防乙醇吸收至关重要。此外，胃排空延迟似乎部分参与了预防作用。
