Makino K, Kamiyama H, Takamura H, Gotoh S, Kobayashi N
Department of Neurosurgery, Asahikawa Red Cross Hospital, Japan.
Ann Nucl Med. 1999 Aug;13(4):261-4. doi: 10.1007/BF03164902.
We report two patients with occlusive cerebrovascular disease who were examined by means of benzodiazepine receptor SPECT(BZR-SPECT) with 123I-iomazenil (IMZ) before extracranial-intracranial bypass surgery (EC/IC bypass). Preoperative low perfusion areas detected by cerebral blood flow SPECT (CBF-SPECT) were divided into two parts on BZR-SPECT images. In the low perfusion areas where the BZR were preserved, regional cerebral blood flow (rCBF) increased on postoperative CBF-SPECT, but where the BZR were not preserved, rCBF did not increase on postoperative CBF-SPECT. On visual inspection, the SPECT images of postoperative CBF-SPECT appeared similar to those of preoperative BZR-SPECT. For evaluation of the ischemic brain condition itself, instead of the cerebral metabolism, the distribution and activity of cerebral neurons indicated by BZR-SPECT with IMZ might be utilized.
我们报告了两名患有闭塞性脑血管疾病的患者，他们在颅外-颅内搭桥手术（EC/IC搭桥）前接受了使用123I-碘美托咪定（IMZ）的苯二氮䓬受体单光子发射计算机断层扫描（BZR-SPECT）检查。通过脑血流单光子发射计算机断层扫描（CBF-SPECT）检测到的术前低灌注区域在BZR-SPECT图像上被分为两部分。在BZR得以保留的低灌注区域，术后CBF-SPECT上的局部脑血流量（rCBF）增加，但在BZR未保留的区域，术后CBF-SPECT上的rCBF没有增加。通过肉眼观察，术后CBF-SPECT的SPECT图像与术前BZR-SPECT的图像相似。为了评估缺血性脑状况本身，或许可以利用IMZ的BZR-SPECT所显示的脑神经元分布和活性，而非脑代谢。
