Goldberger J H, DeLuca F G, Wesselhoeft C W, Randall H T
J Pediatr. 1979 Feb;94(2):325-8. doi: 10.1016/s0022-3476(79)80861-6.
Three children--ages 4 months, 5 months, and 14 years--have been on a program of total parenteral nutrition at home for ten, 23 and 44 months respectively, as of January, 1978. Using a specially designed silicone rubber catheter, placed in the right atrium, total nutritional needs of these children were delivered nightly by family members; the children carried out normal activity during the day with the catheter line maintained by a heparin lock. Normal skeletal development and weight gain have been achieved while allowing these children normal social and psychlogic development outside the hospital. During the course of the therapy the patients had multiple metabolic abnormalities which were successfully treated by replacement therapy. The duration of catheter patency ranged from three to 22 months. Catheter sepsis or mechanical failure occasionally required catheter removal and replacement.
截至1978年1月，三名儿童——年龄分别为4个月、5个月和14岁——已在家中接受全胃肠外营养治疗，时间分别为10个月、23个月和44个月。通过一根专门设计的硅橡胶导管置于右心房，这些儿童的全部营养需求由家庭成员每晚提供；孩子们白天进行正常活动，导管线路通过肝素锁维持。在允许这些儿童在院外正常社交和心理发育的同时，实现了正常的骨骼发育和体重增加。在治疗过程中，患者出现了多种代谢异常，通过替代疗法成功治疗。导管通畅时间为3至22个月。导管败血症或机械故障偶尔需要拔除并更换导管。
