硝酸铅（II）和二硫代氨基甲酸盐类杀菌剂对大鼠肺部的影响。

Effects of lead(II) nitrate and a dithiocarbamate fungicide on the rat lung.

作者信息

Adamis Z, Tátrai E, Honma K, Ungváry G

机构信息

OKK National Institute of Chemical Safety, Budapest, Hungary.

出版信息

J Appl Toxicol. 1999 Sep-Oct;19(5):347-50. doi: 10.1002/(sici)1099-1263(199909/10)19:5<347::aid-jat587>3.0.co;2-3.

DOI:10.1002/(sici)1099-1263(199909/10)19:5<347::aid-jat587>3.0.co;2-3

PMID:10513680

Abstract

The pulmonary toxicity of two potential environmental pollutants was studied in rats 1, 7 and 30 days after a single intratracheal instillation of lead nitrate and Dithane M-45 (mancoceb), either individually or in various combinations. The cell count, protein, phospholipids and lactate dehydrogenase level were determined in the bronchoalveolar lavage fluid, as were the protein, phospholipids and acid phosphatase contents in the lung tissue. Lead nitrate and Dithane M-45 induced acute inflammation reactions with different features. The effects of mixtures of lead nitrate and Dithane M-45 were found to be different from those of the individual components.

摘要

在大鼠经气管内单次滴注硝酸铅和代森锰锌（代森锰锌）后1天、7天和30天，分别单独或联合使用这两种潜在环境污染物，研究了其对大鼠的肺毒性。测定支气管肺泡灌洗液中的细胞计数、蛋白质、磷脂和乳酸脱氢酶水平，以及肺组织中的蛋白质、磷脂和酸性磷酸酶含量。硝酸铅和代森锰锌引起了具有不同特征的急性炎症反应。发现硝酸铅和代森锰锌混合物的作用与单个成分的作用不同。