Synthetic studies of an 18-membered antitumor macrolide, tedanolide. 5. Stereoselective synthesis of the C13-C23 part via condensation of two fragments, C13-C17 and C18-C21, by taking advantage of the 3,4-dimethoxybenzyl protecting group.
作者信息
Zheng B Z, Maeda H, Mori M, Kusaka S, Yonemitsu O, Matsushima T, Nakajima N, Uenishi J
机构信息
Department of Chemistry, Okayama University of Science, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1999 Sep;47(9):1288-96. doi: 10.1248/cpb.47.1288.
PMID:10517009
Abstract
An efficient and stereoselective synthesis of the C13-C23 part (8) was achieved starting from methyl (R)- and (S)-3-hydroxy-2-methylpropionates (9) via coupling of the C13-C17 aldehyde (6), prepared by Evans asymmetric aldol reaction, with the C18-C21 iodoalkene (5b) by taking advantage of the 3,4-dimethoxybenzyl protecting group.
摘要
Zotero 插件