Thieffry D
Unité de Bioinformatique, IBMM-ULB, 12 rue des Professeurs Jeener et Brachet, B-6041 Gosselies, Belgium.
Bioessays. 1999 Nov;21(11):895-9. doi: 10.1002/(SICI)1521-1878(199911)21:11<895::AID-BIES1>3.0.CO;2-F.
Allowing the parallel monitoring of the transcription of thousands of genes, microarrays constitute a powerful technique for functional genomics. In a recent paper, a clustering method and a local alignment software were combined to identify DNA motifs in sets of yeast genes endowed with similar transcription profiles throughout mitosis (1). Identifying various known transcriptional binding sites together with new putative ones, the authors made a significant step towards a systematic characterization of the regulatory structure of genomic networks. BioEssays 1999;21:895-899.
微阵列技术能够同时监测数千个基因的转录情况，是功能基因组学研究中的一项强大技术。在最近的一篇论文中，一种聚类方法与一款局部比对软件相结合，用于在整个有丝分裂过程中具有相似转录谱的酵母基因集中识别DNA基序(1)。作者识别出了各种已知的转录结合位点以及新的假定结合位点，朝着系统表征基因组网络调控结构迈出了重要一步。《生物论文》1999年；21卷：895 - 899页 。
