Zubizarreta P, Chantada G
Department of Pediatric Hematology and Oncology, Hospital de Pediatria 'Juan P. Garrahan', Buenos Aires, Argentina.
Ophthalmic Genet. 1999 Sep;20(3):189-91. doi: 10.1076/opge.20.3.189.2276.
We report an unusual case of a two-year-old girl with metastatic retinoblastoma and massive bone marrow involvement who showed the overt presence of circulating retinoblastoma cells in peripheral blood smears a few days before death. This extended disease developed after an early relapse that followed abandoned primary chemotherapy. To the best of our knowledge, there are no previous reports about the presence of circulating retinoblastoma cells in peripheral blood films. We conclude that the search for bone marrow invasion in patients with disseminated retinoblastoma should be exhaustive to achieve an accurate staging assessment. Peripheral blood smears should be examined cautiously to detect occasional circulating retinoblastoma cells when the bone marrow is massively involved.
我们报告了一例罕见病例，一名两岁女童患有转移性视网膜母细胞瘤且骨髓大量受累，在死亡前几天的外周血涂片上明显出现了循环视网膜母细胞瘤细胞。这种广泛性疾病是在放弃原发性化疗后早期复发后发展而来的。据我们所知，以前没有关于外周血涂片上存在循环视网膜母细胞瘤细胞的报道。我们得出结论，对于播散性视网膜母细胞瘤患者，应全面检查骨髓以进行准确的分期评估。当骨髓大量受累时，应谨慎检查外周血涂片以检测偶尔出现的循环视网膜母细胞瘤细胞。
