Calbet M, Guadaño-Ferraz A, Spier A D, Maj M, Sutcliffe J G, Przewłocki R, de Lecea L
Department of Molecular Biology, MB-10, The Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, CA, USA.
Brain Res Mol Brain Res. 1999 Sep 8;72(1):55-64. doi: 10.1016/s0169-328x(99)00220-x.
Cortistatin (CST) is a presumptive neuropeptide that shares 11 of its 14 amino acids with somatostatin (SST). CST and SST are expressed in partially overlapping but distinct populations of cortical interneurons. In the hippocampal formation, most CST-positive cells are also positive for SST. In contrast to SST, administration of CST into the rat brain ventricles reduces locomotor activity and specifically enhances slow wave sleep. Intracerebroventricular injection of CST or SST has been shown to protect against the neurotoxic effects of kainic acid. Here, we show that CST and SST mRNAs respond differently to kainate-induced seizures. Furthermore, comparison of the upstream sequences from the CST and SST precursor genes reveal that they contain binding motifs for different transcriptional regulatory factors. Our data demonstrate that CST and SST, which are often co-expressed in the same neurons, are regulated by different stimuli.
促皮质素释放抑制因子（CST）是一种推测的神经肽，其14个氨基酸中有11个与生长抑素（SST）相同。CST和SST在皮质中间神经元的部分重叠但不同的群体中表达。在海马结构中，大多数CST阳性细胞也对SST呈阳性。与SST相反，将CST注入大鼠脑室会降低运动活性并特别增强慢波睡眠。脑室内注射CST或SST已被证明可预防红藻氨酸的神经毒性作用。在这里，我们表明CST和SST mRNA对红藻氨酸诱导的癫痫发作反应不同。此外，对CST和SST前体基因上游序列的比较表明，它们含有不同转录调节因子的结合基序。我们的数据表明，经常在同一神经元中共表达的CST和SST受不同刺激的调节。
